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US 2025/0049967 A1Published application
Pet tracers for visualizing gabaa gamma1 receptors
AssigneeHoffmann-La Roche Inc.
InventorsGiuseppe CECERE, Luca Claudio GOBBI, Maria-Clemencia HERNANDEZ, Michael Carl HONER
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Abstract
The present invention provides radiolabeled GABAA γ1 positive allosteric modulators (PAM) that are useful for medical imaging.
Claims9
A compound of formula (I) or (II)
- or a pharmaceutically acceptable salt thereof, wherein said compound comprises a radiolabel.
A method of diagnostic imaging of GABAA γ1 in a mammal, comprising:
- (a) administering to the mammal a detectable quantity of a radiolabeled compound according to acclaim 1, or of a pharmaceutically acceptable salt thereof, and
- (b) detecting the radiolabeled compound when associated with GABAA γ1.
Dependencies are inferred from the claim text.