Back to results
US 2025/0049946 A1Published application
Sulfonato resorcinarene-complexed fluoroquinolones and methods of use
OwnerHarshita Kumari, Suchitra Dilipkumar Panigrahi +1inventors
InventorsHarshita Kumari, Suchitra Dilipkumar Panigrahi, Ramana Reddy Mittapalli
Life of this patent
Estimating the term…
Abstract
Supramolecular inclusion complexes comprising sulfonato methylresorcinarenes according to Formula I and a fluoroquinolone compound are provided. Also provided are pharmaceutical compositions comprising the supramolecular complexes and methods of using the supramolecular complexes to treat bacterial infections, kill or inhibit growth of bacteria, and disrupt bacterial biofilms.
Claims24
A supramolecular complex comprising:
- a macrocycle compound according to Formula I
- wherein:
- R1 is selected from C1-C20 alkyl, C1-C20 alkoxyl, and aryl;
- and
- R2 is selected from H, C1-C20 alkyl, C1-C20 alkoxyl, aryl, and (CH2)nSO3−X+, wherein n is an integer from 1 to 17, and wherein X+ is a cation;
- and
- a fluoroquinolone compound.
4 more elements
A supramolecular complex comprising:
- sulfonato-C-methylresorcin[4]arene (SRsC1);
- and
- a fluoroquinolone compound;
- or a salt thereof.
1 more element
Dependencies are inferred from the claim text.