Method of treatment for solid tumors containing hypoxia and/or stroma features
AssigneeWayne State University
InventorsSamaresh Sau, Arun K. Iyer, Hashem Alsaab
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Abstract
Advancements in solid tumor (e.g., renal cell carcinoma) treatments and imaging are described. The advancements are based on nanoformulations that: (i) overcome deliverability issues associated with anti-cancer compounds; (ii) have increased targeted delivery to tumors, and hypoxic cores of tumors due to the presence of targeting ligands; (iii) have increased delivery to the hypoxic cores of tumors due to engineered shapes; (iv) provide synergistic treatment combinations; and/or (v) overcome cancer cell resistance to therapeutic treatments.
Claims23
A nanoparticle formulation comprising:
- 17% to 30% w/w of a CARP-1 functional mimetic (CFM);
- and
- a styrene maleic anhydride (SMA)—vitamin E tocopheryl polyethylene glycol succinate (TPGS) co-polymer.
A nanoparticle formulation comprising:
- a polymer selected from one or more of:
- DBCO-conjugated vitamin E TPSG, SMA-TPGS;
- HP-β-CD, SBE-β-CD, PC, ceramide, Pluronic® F127, and PLA-PEG;
- a CAIX-targeting ligand;
- and
- a dye.
Dependencies are inferred from the claim text.