US 2025/0049935 A1Published application

Bottlebrush conjugates for use as oligonucleotide enhancers

AssigneeNortheastern University

InventorsKe Zhang, Yuyan Wang

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Abstract

Provided herein are, in various embodiments, are bottlebrush polymer-oligonucleotides conjugates. In certain embodiments, the conjugates are potent in vivo, have improved biopharmaceutical properties, enhanced transfection efficiency, and/or an unconventional biodistribution profile. Also provided herein are pharmaceutical compositions, methods of treatment, and methods of making bottlebrush polymer-oligonucleotide conjugates.

Claims122

Dependent claims

A bottlebrush polymer-oligonucleotide conjugate (conjugate) comprising:

a) a sequence-defined polymer backbone comprising two or more monomers;
b) at least one side chain linked to at least one of the two or more monomers;
and
c) at least one oligonucleotide linked to at least one of the two or more monomers.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 18/720,511Filed 16 Dec 2022
Priority: 16 Dec 2021
Published: 13 Feb 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 47/58
The modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule: obtained by reactions only…
C12N 15/115
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: aptamers, i.e. nucleic acids binding a…

Family

Application63/290,225Us provisional application · filed 16 Dec 2021
US 2025/0049935 A1This patent

From the US filing history. Foreign family members aren’t listed.

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