Drug delivery system for targeted cancer treatment

Abstract

The present invention provides a drug delivery system for targeted cancer treatment, comprising: a GEM-PLGA complex, wherein the complex contains 150 mg of GEM-PLGA, equivalent to 25 mg of gemcitabine (GEM); Acetone in an amount of 10 ml as a solvent for the GEM-PLGA complex; Polyvinyl alcohol (PVA) solution in an amount of 20 ml, with a concentration of 2% w/v, used as a stabilizer for the formulation; and a Layer-by-Layer nanoparticle (LbL-NP) formulation encapsulating the GEM-PLGA complex and configured to release GEM in a controlled manner upon administration. The physiochemical properties of Caps-GEM LbL NPs was evaluated such as particle size, zeta potential, percent entrapment efficiency (% EE), loading of drug and In-vitro drug release behavior. The surface morphology of LbL NP's was evaluated by scanning electronic microscopy (SEM).

Dependencies are inferred from the claim text.