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US 2025/0049928 A1Published application
Anesthetic prodrugs and derivatives thereof for prolonged sensory selective nerve blockage
AssigneeThe Board of Trustees of The University of Alabama
InventorChao Zhao
Life of this patent
Estimating the term…
Abstract
Prodrugs and derivatives of anesthetics (e.g., capsaicin, bupivacaine) and methods of using the same.
Claims42
A compound of Formula I:
- Z-L-X (I)
- or pharmaceutically acceptable salt thereof, wherein:
- Z is selected from the group consisting of capsaicin, bupivacaine, tetracaine, lidocaine, benzocaine, procaine, prilocaine, cinchocaine, and ropivacaine;
- L is an optional divalent linker;
- and
- X is a monosaccharide;
- wherein when L is present, L is covalently bonded to X by —O—, and L is covalently bonded to Z through —O— or —N—.
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A compound of Formula I:
- Z-L-X (I)
- or pharmaceutically acceptable salt thereof, wherein:
- Z is selected from the group consisting of capsaicin, bupivacaine, tetracaine, lidocaine, benzocaine, procaine, prilocaine, cinchocaine, and ropivacaine;
- L is —C(═O)R′C(═O)—, and R′ is C1-4alkyl;
- X is H;
- L is covalently bonded to X by —O—;
- and
- L is covalently bonded to Z through —O— or —N—.
5 more elements
Dependencies are inferred from the claim text.