Pharmaceutical composition comprising p-boronophenylalanine

A pharmaceutical composition comprising boronophenylalanine (BPA) or a pharmaceutically acceptable salt thereof and a 2-hydroxy amine compound (2HA) or a pharmaceutically acceptable salt thereof, wherein the 2HA is selected from the compounds set forth in any one of the formulas I to II or a pharmaceutically acceptable salt thereof, or any combination or mixture thereof:

• wherein R1 and R2 are each independently either H or selected from hydroxy-C1-C6-alkyl, 2-hydroxyethyl, 2,3,4,5,6-pentahydroxyhexyl, carboxy-C1-C6-alkyl, acetyl, C1-C6-alkyl, sulfo-C1-C6-alkyl, 3-sulfopropyl, 2-hydroxy-3-sulfopropyl, 1-sulfo-2-propanyl, 2-sulfoethyl, 3-[2-hydroxy-1,1-bis(hydroxymethyl)ethylamino]-C1-C6-alkyl, and 3-[2-hydroxy-1,1-bis(hydroxymethyl)ethylamino]propyl;
• wherein n is 0 or 1;
• provided that when n is 1, then R3 is absent, and when n is 0, then R3 is selected from H, hydroxy-C1-C6-alkyl, 2-hydroxyethyl, carboxy-C1-C6-alkyl, acetyl, C1-C6-alkyl, sulfo-C1-C6-alkyl and 2-sulfoethyl.