Compositions for Inducing an Immune Response Against Zika Virus
AssigneeThe Trustees of the University of Pennsylvania
InventorsDrew Weismann, Norbert Pardi, Michael Hogan
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Abstract
The present invention relates to compositions and methods for inducing an adaptive immune response against Zika virus (ZIKV) in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof.
Claims20
A composition for inducing an immune response against Zika virus (ZIKV) in a subject, the composition comprising an isolated nucleoside-modified RNA encoding a fragment of SEQ ID NO:
- 2 comprising the pre-membrane (prM) and envelope (E) proteins.
Dependencies are inferred from the claim text.