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US 2025/0049907 A1Published application
Brucella canis vaccine for dogs
AssigneeThe Texas A&M University System
InventorsAngela M. Arenas Gamboa, Thomas A. Ficht
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Abstract
Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.
Claims20
A vaccine composition comprising:
- a Brucella canis comprising one or more attenuating gene knockouts;
- and
- a pharmaceutically acceptable vaccine carrier, wherein the vaccine is used for a prophylaxis, an amelioration of symptoms, a treatment, or any combinations thereof against brucellosis in a human or an animal subject.
A vaccine composition comprising:
- a Brucella canis comprising one or more attenuating gene knockouts selected from at least one of ΔvjbR and 16M ΔvjbR;
- and
- a pharmaceutically acceptable vaccine carrier.
A method for prophylaxis, amelioration of symptoms, or any combinations thereof against brucellosis in a human or animal subject comprising the steps of:
- identifying the human or animal subject in need of the prophylaxis, amelioration of symptoms, or any combinations thereof against brucellosis;
- and
- administering a therapeutically effective amount of a vaccine composition to the human or animal subject for the prophylaxis, amelioration of symptoms, or any combinations thereof against brucellosis, wherein the vaccine comprises:
- a Brucella canis strain comprising one or more attenuating gene knockouts;
- and
- a pharmaceutically acceptable carrier.
3 more elements
Dependencies are inferred from the claim text.