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US 2025/0049889 A1Published application
Neuroprotective compositions and use thereof
AssigneeNanoNeuron Therapeutics, Inc.
InventorsQiang Feng, Gina Elsen, Po-Hsuen Chen, Shi-Jiang Lu
Life of this patent
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Abstract
The present disclosure relates generally to biocompatible nanoparticles, and in particular, neuroprotective nanoparticles comprising ciliary neurotrophic factor and/or oncostatin M. Methods for making and using the same are also provided.
Claims15
A composition for use in the treatment of a disease or condition in a subject in need thereof, comprising:
- a plurality of nanoparticles comprising dextran sulfate and chitosan;
- and
- an effective amount of a neurotrophic factor associated with the nanoparticles, wherein the neurotrophic factor is selected from the group consisting of Brain-derived neurotrophic factor (BDNF), Nerve growth factor (NGF), Neurotrophin-3 (NT-3), Neurotrophin-4 (NT-4), Ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), prolactin, growth hormone, leptin, interferons (i.e., interferon-α, -β, and -γ), oncostatin M (OSM), Glial cell line-derived neurotrophic factor (GDNF), Artemin, Neurturin, Persephin, and Ephrins.
Dependencies are inferred from the claim text.