Methods and compositions for modulating the myeloid arm of the immune system
AssigneeFred Hutchinson Cancer Center
InventorsLev Silberstein, Hans-Peter Kiem, Stefan Radtke
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Abstract
Methods and compositions for modulating the myeloid arm of the immune system are described. The methods and compositions modulate the myeloid arm of the immune system by stimulating or inhibiting Sema4 and/or a PlexinD1 receptor. Stimulating Sema4 and/or a PlexinD1 receptor down-regulates or dampens the myeloid arm of the immune system while inhibiting Sema4 and/or a PlexinD1 receptor up-regulates or heightens the myeloid arm of the immune system. The ability to modulate the myeloid arm of the immune system provides many advances such as reducing immune-responsiveness to various forms of stress and enhancing immune responsiveness to physiological challenges.
Claims46
A method of protecting myeloid-biased hematopoietic stem cells (myHSC) from a proliferative challenge, the method comprising administering a therapeutically effective amount of a PlexinD1 receptor agonist or a Sema4a agonist to the myHSC.
A method for maintaining myeloid-biased hematopoietic stem cells (myHSC) in a subject in need thereof comprising administering a therapeutically effective amount of a composition that signals the Sema4a/PlexinD1 receptor signaling pathway in the subject, thereby maintaining the myHSC in the subject in need thereof.
A method for modulating the balance of immune cells in the bone marrow of a subject, the method comprising stimulating Sema4a and/or a PlexinD1 receptor in the subject.
A method of modulating the activation state of the myeloid arm of immune system comprising stimulating or inhibiting Sema4a and/or a PlexinD1 receptor.
A composition comprising a therapeutically effective amount of Sema4a and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.