Hyaluronic acid binding peptide as a therapeutic to control fibroblast activation and fibrotic capsule formation
AssigneeSouth Dakota Board of Regents
InventorsTUGBA OZDEMIR, BETH BLAKE
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Abstract
Articles, such as implants and medical devices, treated with a hyaluronic acid binding peptide are provided. Articles are coated with a surface functionalizing agent which bind to and immobilize the hyaluronic acid binding peptide. Methods of improving and/or reducing foreign body reaction to an article are also provided, as are methods of decreasing inflammation, promoting wound healing, and treating dermal conditions.
Claims20
A method of decreasing inflammation and/or promoting wound healing in a patient, comprising:
- providing to the patient a biomaterial comprising a hyaluronic acid binding peptide (HABP), wherein the HABP increases hyaluronic acid (HA) deposition in an area surrounding the biomaterial.
An article comprising:
- a coating of a surface functionalizing agent on a surface of the article, wherein a hyaluronic acid binding peptide (HABP) is bound to the surface functionalizing agent;
- wherein the surface functionalizing agent is selected from the group consisting of an aminoorganosilane, a maleimide, a thiol-maleimide, a glutaraldehyde, a dopamine, a hydroxypyrrolidine, a diisothiocyanate, a catechol, a polyester, and an aldehyde.
A method of improving and/or reducing foreign body reaction to an article, comprising:
- coating at least one surface of the article with a surface functionalizing agent, wherein a hyaluronic acid binding peptide (HABP) is bound to the surface functionalizing agent to form a treated article;
- and
- providing the treated article to a patient, wherein said providing comprises at least partially implanting the treated article within the patient.
Dependencies are inferred from the claim text.