Mechanism based quality control for botanical medicine
AssigneeYale University
InventorYung-Chi CHENG
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Abstract
The invention relates to methods of evaluating the quality of a batch of an herbal composition, the method comprising subjecting a test batch of the herbal composition to one or more biological analysis methods and comparing the results derived from the test batch to the results of a known batch of herbal composition which has a known in vivo effect.
Claims13
1-13. (canceled)
A method of treating a subject with cancer, the method comprising evaluating the quality and potential in vivo efficacy of a test batch of an herbal composition by subjecting the test batch of the herbal composition to one or more biological analysis methods selected from:
- (a) a signaling transduction activity response assay;
- and
- (b) a gene expression assay;
- comparing the results of the biological analysis method(s) with results derived from a known batch of the herbal composition which has a known level of in vivo activity;
- wherein if the test batch results have a correlation coefficient of between 0.90 and 1.0 with the known batch results, then the test batch is determined to have sufficiently similar quality as the known batch and potential in vivo activity,
- and wherein if the test batch of the herbal composition is determined to have sufficiently similar quality as the known batch, administering a therapeutically effective amount of the test batch of the herbal composition to the subject;
- and
- wherein the herbal composition comprises one or more compositions selected from the group consisting of herbal extracts of Scutellaria baicalensis(S), Glycyrrhiza uralensis (G), Paeonia lactiflora (P), and Ziziphus jujuba (Z), and any fractions thereof.
(canceled)
Dependencies are inferred from the claim text.