Rhodiola rosea nanoemulsion and preparation method thereof
AssigneeMd Research Ltd
InventorsBenni Iskandar, Ching-Peng Wei, Ching Kuo Lee
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Abstract
Provided is a Rhodiola rosea nanoemulsion, comprising Rhodiola rosea extract, surfactant, cosurfactant and oil. The surfactant includes diethylene glycol monoethyl ester or polysorbate 80, the cosurfactant includes polysorbate 80, sorbitan oleate 80, or caprylocaproyl polyoxyl-8 glycerides (Labrasol®), and the oil includes Labrafac™ oil or soybean oil, and Rhodiola rosea extract coated in oil-in-water form. Also provided is a method for preparing the Rhodiola rosea nanoemulsion, so as to provide the Rhodiola rosea nanoemulsion suitable for drug delivery.
Claims17
A Rhodiola rosea nanoemulsion, comprising:
- Rhodiola rosea extract;
- a surfactant comprising diethylene glycol monoethyl ester or polysorbate 80;
- a cosurfactant comprising polysorbate 80, sorbitan oleate 80, or caprylocaproyl polyoxyl-8 glycerides;
- and
- an oil comprising propylene glycol dicaprylocaprate or soybean oil, and the Rhodiola rosea extract coated in oil-in-water form.
A method for preparing Rhodiola rosea nanoemulsion, comprising:
- providing a Rhodiola rosea extract;
- mixing the Rhodiola rosea extract and an oil to obtain an oil phase component;
- mixing a surfactant and a cosurfactant to obtain a water phase component;
- adding the oil phase component into the water phase component to form oil-in-water until emulsified to obtain the Rhodiola rosea nanoemulsion,
- wherein the surfactant comprises diethylene glycol monoethyl ester or polysorbate 80,
- wherein the cosurfactant comprises polysorbate 80, sorbitan oleate 80, or caprylocaproyl polyoxyl-8 glycerides,
- wherein the oil comprises propylene glycol dicaprylocaprate, soybean oil,
- wherein a combination that when the surfactant is the diethylene glycol monoethyl ester, the cosurfactant is the sorbitan oleate 80, and the oil is soybean oil is excluded.
Dependencies are inferred from the claim text.