Spray dried inhalable biotherapeutics for the treatment of disease
AssigneeAlveolus Bio, Inc.
InventorAndrew O'Connor
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Abstract
The technology described herein is directed to spray-dried biotherapeutic matrix compositions comprising a bacterial preparation, which is formulated for administration by inhalation. Also described herein unit dosage forms of such spray-dried biotherapeutic matrix compositions, devices comprising such pharmaceutical compositions, methods of producing such pharmaceutical compositions, and methods of treating diseases, such as bronchopulmonary diseases, among others, using such spray-dried biotherapeutic matrix compositions.
Claims163
A spray-dried biotherapeutic matrix composition comprising a bacterial preparation, wherein the matrix composition is formulated for administration by inhalation.
An inhalation device for bronchopulmonary delivery comprising:
- a) an inhaler;
- and
- b) a container containing a spray-dried biotherapeutic matrix composition comprising a bacterial preparation.
A method of preparing a spray-dried biotherapeutic matrix composition comprising a bacterial preparation, comprising:
- a) preparing a liquid feedstock comprising the bacterial preparation;
- b) introducing droplets of the liquid feedstock through an atomization nozzle into a drying chamber;
- c) exposing the liquid feedstock droplets to heated, pressurized gas in the drying chamber to create dried particles;
- and
- d) isolating dried particles of a predetermined range of diameters in a cyclone chamber, wherein the isolated dried particles comprise the spray-dried biotherapeutic matrix composition.
A method of preparing a spray-dried biotherapeutic matrix composition comprising a bacterial preparation, comprising:
- a) obtaining a liquid feedstock comprising the bacterial preparation;
- b) introducing droplets of the liquid feedstock through an atomization nozzle into a drying chamber;
- c) exposing the liquid feedstock droplets to heated, pressurized gas in the drying chamber to create dried particles;
- and
- d) isolating dried particles of a predetermined range of diameters in a cyclone chamber, wherein the isolated dried particles comprise the spray-dried biotherapeutic matrix composition.
A method of delivering a spray-dried biotherapeutic matrix composition comprising a bacterial preparation to a subject, comprising:
- a) obtaining an inhalation device for bronchopulmonary delivery comprising:
- i) an inhaler;
- and
- ii) a container containing a spray-dried biotherapeutic matrix composition comprising a bacterial preparation;
- b) activating the inhaler to cause aerosolization or dispersal of the spray-dried biotherapeutic matrix composition;
- and
- d) inhaling the aerosolized or dispersed spray-dried biotherapeutic matrix composition.
A method of treating a subject in need thereof comprising administering through inhalation an effective dose of a spray-dried biotherapeutic matrix composition comprising a bacterial preparation.
A unit dosage form comprising at least 1 mg of a spray-dried biotherapeutic matrix composition comprising a bacterial preparation.
A unit dosage form comprising at least 1 mg of a spray-dried biotherapeutic matrix composition comprising at least 104 CFU bacteria per unit dose.
Dependencies are inferred from the claim text.