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AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsJae-Yol LIM, Yeo-Jun YOON, Yongpyo HONG, Ye-Jin JEONG
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The present disclosure relates to a method for isolating, maintaining, proliferating and differentiating monoclonal cells derived from human salivary gland epithelial stem cells or progenitor cells, and a production method for extracellular vesicles for treating salivary gland diseases. More specifically, conditions for isolating monoclonal salivary gland epithelial cells through an optimized subfractionation culturing method from a small amount of major salivary gland or minor salivary gland tissue obtained during surgery or biopsy processes have been established, and culture medium conditions for enabling long-term culture of salivary gland epithelial stem cells or progenitor cells in 2D have been established. Such high-purity monoclonal cells derived from human salivary gland epithelial stem cells or precursor cells are expected to be utilized not only as cell therapy products for fundamental treatment of salivary gland dysfunction and as candidates for extracellular vesicles, but also widely throughout salivary gland studies such as disease modeling, pathology research, drug screening, toxicity evaluation, and genetic manipulation.
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A method for culturing monoclonal cells derived from salivary gland epithelial stem cells or progenitor cells, comprising:
A production method for extracellular vesicles from monoclonal cells derived from salivary gland epithelial stem cells or progenitor cells, comprising:
A method for treating salivary gland inflammatory diseases, comprising:
Dependencies are inferred from the claim text.