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AssigneePaean Biotechnology Inc.
InventorsYoung Cheol Kang, Kyuboem Han, Chun-Hyung Kim, Soomin Kim
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The present invention relates to a method for freezing and/or freeze-drying mitochondria isolated from cells, and a use of frozen and/or freeze-dried mitochondria. The frozen mitochondria according to the present invention showed similarity to non-frozen mitochondria in terms of anti-inflammatory activity and activity of energy metabolism-related enzymes. Also, the freeze-dried mitochondria showed similar levels of anti-inflammatory activity, activity of energy metabolism-related enzymes, and long-term preservation efficacy after recovery to those in the mitochondria before freeze-drying. Therefore, allowing isolated mitochondria to find a wide spectrum of applications in the treatment of various diseases caused by mitochondrial dysfunction or impairment, the frozen and/or freeze-dried mitochondria according to the present invention is expected to greatly enhance the commercial availability of therapeutics containing mitochondria.
Frozen and/or freeze-dried mitochondria.
A method for stably freezing isolated mitochondria.
A method for stably freeze-drying isolated mitochondria.
A cryoprotectant for mitochondria comprising glycine.
A composition for freezing mitochondria, comprising a cryoprotectant for mitochondria comprising glycine;
A pharmaceutical composition for preventing or treating a disease, comprising frozen and/or freeze-dried mitochondria as an active ingredient.
An long-term preservation solution composition kit for preserving isolated cells, tissues, or organs, comprising frozen and/or freeze-dried mitochondria and a long-term preservation solution.
A use of frozen and/or freeze-dried mitochondria for the prevention or treatment of a mitochondria-related disease.
A method for preventing or treating a mitochondria-related disease, comprising administering frozen and/or freeze-dried mitochondria.
Dependencies are inferred from the claim text.