Treatment of Spinal Cord Injury with T regulatory Cells
AssigneeCreative Medical Technologies, Inc.
InventorsThomas Ichim, Courtney Bartlett, Timothy Warbington, Amit Patel
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Abstract
Methods and compositions of matter useful for reducing extent of spinal cord injury and/or reversion of spinal cord injury gliosis are disclosed. T regulatory cells can be administered systemically and/or locally to a patient suffering from spinal cord injury. T regulatory cells can be modulated by engineering either through gene modification or culture conditions in order to augment regenerative/antifibrotic properties. Utilizing pluripotent stem cell derived T regulatory cells for spinal cord injury and chimeric antigen receptor T cells.
Claims20
A method of treating spinal cord injury comprising administration of a population of cells in which one cell type of said populations is a T cell possessing ability to inhibit proliferation of other T cells.
A method of treating spinal cord injury comprising administration of T regulatory cells in the area of injury using a localization means.
Dependencies are inferred from the claim text.