Methods and compositions for altering a tumor microbiome
AssigneeBoard of Regents, The University of Texas System
InventorRaghu KALLURI
Life of this patent
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Abstract
Aspects of the present disclosure relate to methods and compositions for altering a tumor microbiome. Certain aspects are directed to methods for manipulating a tumor microenvironment for promotion of a tumor restraining microbiome and treatment of cancer. Particular aspects include methods for treating cancer comprising administration of an immunotherapy and an agent capable of disrupting an interaction between α3β1 integrin and α1 homotrimeric type I collagen.
Claims99
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that disrupts an interaction between α3β1 integrin and α1 homotrimeric type I collagen.
A method of treating a subject for pancreatic cancer, the method comprising:
- (a) isolating bacteria from the tumor microbiome;
- and
- (b) administering to the subject an effective amount of:
- (i) an agent that disrupts an interaction between α3β1 integrin and α1 homotrimeric type I collagen;
- and
- (ii) an immunotherapy.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates angiogenesis in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits angiogenesis in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates epithelial to mesenchymal transition in cells of the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits epithelial to mesenchymal transition in cells of the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates pericyte proliferation in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits pericyte proliferation in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates cellular metabolism in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits cellular metabolism in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that activates fibroblast proliferation in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits fibroblast proliferation in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that degrades extracellular matrix in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates cell-cell adhesion in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits cell-cell adhesion in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates stromal cell signaling in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits stromal cell signaling in the tumor microenvironment.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that disrupts the lymphatic system.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that stimulates lymphangiogenesis.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that inhibits lymphangiogenesis.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that attenuates hypoxia status.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that enhances hypoxia status.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that modifies macrophage polarization.
A method for altering a tumor microbiome comprising administering to a tumor microenvironment an effective amount of an agent that modifies macrophage differentiation.
Dependencies are inferred from the claim text.