Iron oxide nanoparticle-mediated radiation delivery for targeted cancer treatment
AssigneeUniversity of Washington
InventorsMiqin ZHANG, Peter A. CHIARELLI, Richard REVIA, Zachary STEPHEN, Forrest M. KIEVIT, Kui WANG, Richard G. ELLENBOGEN
Life of this patent
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Abstract
Method for nanoparticle-mediated deposition of radiation (NMDR) and targeted radiation therapies using a biodegradable and bioabsorbable iron oxide nanoparticle with a biocompatible coating that is effective to overcome various extra- and intra-cellular barriers and selectively accumulate in solid and metastatic tumors to improve the energy transfer of conventional radiotherapy
Claims18
A method for targeted radiation therapy in a subject, comprising:
- (a) administering to a subject an iron oxide nanoparticle having an iron oxide core, a biocompatible coating surrounding the core, and a targeting agent associated with the coating, to provide a site in the subject having accumulated iron oxide nanoparticles;
- and
- (b) applying γ- and/or x-ray irradiation to the subject at the site having accumulated iron oxide nanoparticles to produce photoelectrons at the site.
A method for producing photoelectrons at a select site in a subject, comprising:
- (a) administering to a subject an iron oxide nanoparticle having an iron oxide core, a biocompatible coating surrounding the core, and a targeting agent associated with the coating, to provide a site in the subject having accumulated iron oxide nanoparticles;
- and
- (b) applying γ- and/or x-ray irradiation to the subject at the site having accumulated iron oxide nanoparticles to produce photoelectrons at the site.
A method for treating a cancer in a subject, comprising:
- (a) administering to a subject an iron oxide nanoparticle having an iron oxide core, a biocompatible coating surrounding the core, and a targeting agent associated with the coating, to provide a site in the subject having accumulated iron oxide nanoparticles;
- and
- (b) applying γ- and/or x-ray irradiation to the subject at the site having accumulated iron oxide nanoparticles to produce photoelectrons at the site, wherein the site is a cancerous tumor.
18-19. (canceled)
Dependencies are inferred from the claim text.