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US 2025/0049842 A1Published application
Therapeutic blood-acid-shifting compositions and methods
OwnerJames D. Ervininventor
Life of this patent
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Abstract
A composition for intravenous injection into an individual's body tissue includes an acid with a pKa less than 3.0 and a conjugate base with therapeutically beneficial properties. The composition has utility in a method of shifting blood-acid for various therapeutic purposes.
Claims21
A method of shifting blood acid for therapeutic purpose while presenting a therapeutic conjugate base, the method comprising:
- administering to a subject a therapeutically effective amount of a composition including a buffer solution having at least one pharmaceutical grade acid containing at least one therapeutic conjugate base, and at least one pharmaceutical grade pH buffering agent in a sterile aqueous solution,
- wherein the pharmaceutical grade acid comprises an acid selected from a group consisting of Hydroiodic Acid, Perchloric Acid, Chloric Acid, Sulfuric Acid, Nitric Acid, Folic Acid, Sulfurous Acid, Sulfuric Acid, Glutamic Acid, and Pyruvic Acid, or a combination of two or more thereof,
- wherein the therapeutic conjugate base comprises a base selected from a group consisting of Iodine, Perchlorate, Chlorate, Sulfate, Nitrate, Folate, Bisulfite, Glutamate, and Pyruvate, or a combination of two or more thereof, or ionized or radioactive forms thereof,
- wherein the concentration of the pharmaceutical grade acid and the pharmaceutical grade pH buffering agent in the buffer solution is sufficient to provide a total acid content of from 60 mmol/L to 3,000 mmol/L when administered to a subject, and
- wherein the selected pharmaceutical grade acid and the pharmaceutical grade pH buffering agent or agents provide a buffer solution pH of between 1.8 and 8.6 when administered to a subject.
2 more elements
A pharmaceutical composition for intravenous delivery to a mammal, the pharmaceutical composition comprising:
- an intravenous buffer solution comprising at least one pharmaceutical grade acid containing at least one therapeutic conjugate base;
- and
- at least one pharmaceutical grade pH buffering agent in a sterile aqueous solution.
Dependencies are inferred from the claim text.