Antiviral use of bisepoxylignan compound, and bisepoxylignan composition and preparation of bisepoxylignan compound

A synthesis method of liangiaoxinside, comprising the following steps:

• 1) obtaining corresponding β-keto esters (a compound of formula 4) and (a compound of formula 9) by taking vanillin (a compound of formula 1) and 3-hydroxy-5 methoxybenzaldehyde (a compound of formula 6) as raw materials via phenolic hydroxyl protection, oxidization and Claisen condensation reaction;
• then converting the β-keto esters into corresponding sodium salt (a compound of formula 5) and bromide (a compound of formula 10) respectively, and then performing a coupling reaction on the two fragments to obtain an intermediate (a compound of formula 11);
• 2) obtaining aglycone (a compound of formula 14) from the intermediate (the compound of formula 11) via a reduction reaction and a ring-closing reaction;
• 3) obtaining a target product (a compound of formula 17) from the aglycone (the compound of formula 14) via glycosylation and protecting group removal;
• and
• a reaction formula is as follows:
• in which:
• a. benzyl chloride;
• b. potassium permanganate;
• c. thionyl chloride/ethyl acetoacetate/sodium ethoxide;
• d. sodium ethoxide;
• e. tert-butyldimethylchlorosilane;
• f. bromine water;
• g. methylene chloride;
• h. lithium aluminum hydride;
• i. methylsulfonyl chloride/pyridine;
• j. palladium carbon/hydrogen;
• k. acetylglucosyl trichloroethanimidate;
• l. sodium methoxide;
• and m. tetrabutylammonium fluoride.