Crystalline form of glp-1 receptor agonist and preparation method therefor
AssigneesJiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
InventorsGujun Xu, Weldong Lu, Junran Yang, Zhenxing Du, Qiyun Shao
Life of this patent
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Abstract
A crystalline form of a GLP-1 receptor agonist and a preparation method therefor. The agonist is a compound 2-((4-((S)-3-(4-chloro-2-fluorophenyl)-2,3-dihydrobenzo[b][1,4]dioxane-5-yl)piperidin-1-yl)methyl)-1-(((S)-oxe-tan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid.
Claims16
(canceled)
Crystal form A, B1, B2, B3, C, D, E, F or G of compound 2-((4-((S)-3-(4-chloro-2-fluorophenyl)-2,3-dihydrobenzo[b][1,4]dioxan-5-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid,
- wherein (1) an X-ray powder diffraction pattern of the crystal form A expressed with diffraction angle 2θ has characteristic peaks at 9.587, 10.216, 11.812, 18.204, and 23.404;
- (2) an X-ray powder diffraction pattern of the crystal form B1 expressed with diffraction angle 2θ has characteristic peaks at 8.135, 8.915, 11.259, 11.508, 19.024, and 25.271;
- (3) an X-ray powder diffraction pattern of the crystal form B2 expressed with diffraction angle 2θ has characteristic peaks at 8.182, 8.839, 10.401, 11.168, and 18.906;
- (4) an X-ray powder diffraction pattern of the crystal form B3 expressed with diffraction angle 2θ has characteristic peaks at 10.548, 11.496, 17.557, 19.135, 19.751, and 25.360:
- (5) an X-ray powder diffraction pattern of the crystal form C expressed with diffraction angle 2θ has characteristic peaks at 10.094, 11.511, 17.378, and 20.113:
- (6) an X-ray powder diffraction pattern of the crystal form D expressed with diffraction angle 2θ has characteristic peaks at 10.940, 12.216, 18.344, 19.931, and 22.979:
- (7) an X-ray powder diffraction pattern of the crystal form E expressed with diffraction angle 2θ has characteristic peaks at 11.591, 17.645, 19.060, 20.066, 20.667, and 26.987:
- (8) an X-ray powder diffraction pattern of the crystal form F expressed with diffraction angle 2θ has characteristic peaks at 9.543, 19.405, and 22.153;
- and
- (9) an X-ray powder diffraction pattern of the crystal form G expressed with diffraction angle 2θ has characteristic peaks at 9.096, 11.107, 17.239, and 17.744.
3-10. (canceled)
(canceled)
Dependencies are inferred from the claim text.