Autophagy inducing compounds and uses thereof, in particular for a systemic treatment of diseases and conditions

A pharmaceutical composition comprising one or more of a compound according to Formula (I),

• a physiologically acceptable salt of the compound according to Formula (I), a solvate of the compound according to Formula (I), a hydrate of the compound according to Formula (I), an enantiomer of the compound of Formula (I), and a polymorph of the compound according to Formula (I),
• wherein
• X is independently selected from chemically possible combinations of C, N, O, and S, and is optionally substituted with one of —CH3, —CH2—CH3 or COOH;
• R1 is selected from cyclic C5 or C6 alkyl, optionally comprising chemically possible N, O, and S, and optionally mono- or bi-substituted with one or more of —CH3, —NH2, —COOH, C1 to C4 alkoxy, halo, trifluoromethyl, and trifluoromethoxy;
• R2 is selected from H, CH3, straight or branched C2 to C6 alkyl, optionally comprising at least one of chemically possible N, O, S, and optionally substituted with one of —CH3, —NH2, —OH, —COOH, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptane, and bicyclo[3.1.1]heptane, bicyclo[2.2.2]octane, optionally comprising chemically possible N, O, and S, and optionally substituted with one of —CH3, —CH2—CH3, —OH, -isopropyl, —COOH, —COOCH3, —CH2-cyclohexyl, and NH2;
• R3 is selected from H, straight or branched C1 to C6 alkyl, optionally substituted with one of —CH3, —OH, —CH2—CH3, —NH2, —CH2—NH2, —CH2—NH—CH3, —COOH, optionally comprising chemically possible one or more N, O, and S;
• the C1 to C4 alkoxy, optionally at least one of chemically possible one or more N, O, and S, and optionally mono- or bi substituted with, —NH2, —OH, —COOH;
• cyclopropyl, cyclobutyl, optionally comprising chemically possible at least one of one or more N, O, S, and optionally mono- or bi substituted with one or more of —CH3, —CH2—CH3, —NH2, —CH2—NH2, —CH2—NH—CH3, —OH, —COOH;
• with the provisio that R2 and R3 are not both H or CH3;
• R2 and R3 may be connected to form a 4-membered, 5-membered, 6-membered, 7-membered ring, a bicyclic ring structure of at least one of fused cyclopentyl and cyclohexyl, bicyclo[3.1.1]heptane, optionally comprising chemically possible one or more N, O, and S, and optionally being mono- or bi-substituted with one or more of straight and branched C1 to C6 alkyl, optionally substituted with one or more of —CH3, —OH, —CH2—CH3, —NH2, —NH—CH3, —CH2—NH2, —CH2—NH—CH3,—OH, —COOH, —COOCH3, ═O, isopropyl, sulfonamide, and optionally including chemically possible one or more N, O, and S;
• with the provisio that R2, R3, or the combination thereof comprises at least one NH or NH2.