Inhibition of sterol response element binding proteins as atarget for selective elimination of senescent cells
AssigneeTrustees of Tufts College
InventorChristopher Wiley
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Abstract
Disclosed are methods of treating diseases or disorders associated with cellular senescence. The methods include administering an inhibitor of sterol response element binding proteins (SREBPs).
Claims23
(canceled)
A method of killing senescent cells in a subject in need thereof, the method comprising administering a therapeutically effective amount of a sterol response element binding protein (SRE-BP) activation inhibitor in an amount sufficient to kill senescent cells in the subject.
A method of treating non-alcoholic fatty liver disease (NAFLD) in a subject in need thereof, the method comprising administering a therapeutically effective amount of a sterol response element binding protein (SRE-BP) activation inhibitor to the subject to treat the NAFLD.
18-19. (canceled)
A kit comprising:
- a. reagents for detecting cellular senescence in a subject's cells;
- and
- b. one or more sterol response element binding protein (SRE-BP) activation inhibitor.
24-25. (canceled)
Dependencies are inferred from the claim text.