Compositions and Methods for Treating Cancers of The Central Nervous System (CNS), Including Glioblastoma and Chemoresistant CNS Tumors, And Related Compositions and Methods for Inhibiting and Eliminating CNs Cancer Stem Cells

A method of treating or preventing a central nervous system (CNS) cancer in a mammalian subject, comprising:

• Administering to the subject a lucanthone compound or composition coordinately with a temozolomide compound or composition, in respective amounts, dosages or regimens effective to coordinately or complementarily reduce one or more adverse clinical symptom(s) of the CNS cancer, and/or to extend average survival among treated subjects.

A pharmaceutical composition or kit for treating or preventing a central nervous system (CNS) cancer in a mammalian subject, comprising:

• A lucanthone compound or composition co-formulated or packaged for coordinate clinical use with a temozolomide compound, in respective amounts or dosages to effectively reduce one or more adverse clinical symptom(s) of the CNS cancer, and/or to extend average survival among treated subjects.

A method of treating or preventing a central nervous system (CNS) cancer in a mammalian subject, comprising:

• Administering to the subject a lucanthone compound or composition coordinately with ionizing radiation, in respective amounts, dosages or regimens effective to reduce one or more adverse clinical symptom(s) of the CNS cancer, and/or to extend average survival among treated subjects.