Composition for preventing or treating alzheimer's disease comprising phospholipase c activator as an active ingredient
AssigneeKorea University Research and Business Foundation
InventorsJeehyun KWAG, Jaedong LEE
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Abstract
The present invention relates to a composition for preventing or treating Alzheimer's disease, comprising a phospholipase C (PLC) activator as an active ingredient. A composition comprising the PLC activator of the present invention as an active ingredient restores the S-eCB mobilization suppressed by AβO, recovers the synaptic plasticity impaired by AβO, and not only recovers PLCβ1 protein levels to normal levels in AβO-treated mouse hippocampal slices and 5XFAD mouse hippocampal slices in the chronic stage of AD, but also recovers contextual fear memory impairment in AD mice, and thus is expected to be usefully used for preventing or treating Alzheimer's disease.
Claims5
A method for diagnosing Alzheimer's disease, the method comprising measuring the activity level of PLCβ1 protein in a biological sample isolated from a subject.
Dependencies are inferred from the claim text.