Transdermal Delivery Systems and Methods for Inhibiting, Stopping, Blocking, or Modulating Glutaminolysis, Glutamine, and Other Glutaminolysis Catalyzing Enzymes Across Multiple Metabolic Pathways in Human Beings and Animals

A method for transdermal delivery of molecules that inhibit, stop, block, or modulate glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals, the method comprising the step of:

• administering said molecules via a transdermal delivery system, wherein the transdermal delivery system is a spray or a mist designed for application to the skin, the spray or a mist comprising a liquid formulation of the spray or mist for delivery of an active molecule, wherein the liquid formulation of the spray or mist comprises specific inhibitors, solvents, surfactants, and stabilizers, and wherein the active molecule is a molecule that inhibits, stops, blocks, or modulates glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals.

A method for transdermal delivery of molecules that inhibit, stop, block, or modulate glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals, the method comprising the step of:

• the transdermal delivery system is a transdermal patch system designed for application to the skin for the delivery of an active molecule, wherein the transdermal patch system comprises a backing layer, an adhesive layer, and a reservoir containing the active molecule, and wherein the active molecule is a molecule that inhibits, stops, blocks, or modulates glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals.

A method for transdermal delivery of molecules that inhibit, stop, block, or modulate glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals, the method comprising the step of:

• the transdermal delivery system is a plug or patch designed for application to the skin for delivery of an active molecule and is implantable in the skin, wherein the plug or patch comprises biocompatible materials and release active molecules from reservoirs comprising an active molecule, wherein the plug or patch is implanted subcutaneously or subdermally, and wherein the active molecule is a molecule that inhibits, stops, blocks, or modulates glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals.

A method for transdermal delivery of molecules that inhibit, stop, block, or modulate glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals, the method comprising the steps of:

• the transdermal delivery system is a transdermal injection or subdermal injection designed for application to the skin for delivery of an active molecule, wherein transdermal injection or subdermal injection comprises a delivery device, and wherein the active molecule is a molecule that inhibits, stops, blocks, or modulates glutaminolysis, glutamine, and other glutaminolysis catalyzing enzymes across multiple metabolic pathways in human beings and animals.