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US 2025/0049731 A1Published application
Designed antibody-bound nanoparticles
AssigneeUniversity of Washington
InventorsRobert Divine, Ivan Vulovic, David Baker, William H. Sheffler, Franziska Seeger
Life of this patent
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Abstract
Polypeptides are disclosed comprising an (Fc) binding domain, a helical polypeptide monomer, and an oligomer domain, polymers thereof, and uses thereof.
Claims30
An Antibody Cage (AbC) nanoparticle, comprising:
- (a) a plurality of antibodies, each antibody comprising at least two fragment crystallizable (Fc) domains, and
- (b) a plurality of cyclic oligomers, each cyclic oligomer comprising a polypeptide comprising:
- (i) an Fc-binding domain,
- (ii) a monomer domain to position the Fc-binding domains to promote assembly of the nanoparticle, and
- (iii) an oligomer domain to assemble the polypeptides to form the cyclic oligomer.
- wherein the Fc domains of the plurality of antibodies non-covalently interact with Fc-binding domains of the plurality of cyclic oligomers to form the nanoparticle.
3 more elements
A polypeptide comprising:
- (i) an Fc-binding domain,
- (ii) a monomer domain to position the Fc-binding domains to promote assembly of the nanoparticle, and
- (iii) an oligomer domain to assemble the polypeptides to form the cyclic oligomer.
Dependencies are inferred from the claim text.