Poegma-based lipid nanoparticles
OwnerAshutosh Chilkoti, Soumen Saha +3inventors
InventorsAshutosh Chilkoti, Soumen Saha, Parul Sirohi, Angus Hucknall, Sonal Deshpande
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Abstract
Disclosed herein are lipid nanoparticles including a POEGMA-lipid conjugate that can effectively encapsulate and deliver therapeutics without the immune consequences suffered by PEG-based counterparts. An example lipid nanoparticle includes an ionizable lipid, a phospholipid, a sterol, a POEGMA-lipid conjugate, and a therapeutic. Also disclosed herein are pharmaceutical compositions that include the POEGMA-based lipid nanoparticles, methods of treating a disease or disorder, and methods of delivering a therapeutic to a cell.
Claims27
A lipid nanoparticle comprising:
- an ionizable lipid;
- a phospholipid;
- a sterol;
- a poly[oligo (ethylene glycol) ether methacrylate] (POEGMA)-lipid conjugate at less than 10 mol %, wherein the POEGMA has a number average molecular weight of less than 100 kDa;
- and
- a therapeutic.
A lipid nanoparticle comprising:
- (heptadecan-9-yl 8-((2-hydroxyethyl) (6-oxO-6-(undecyloxy) hexyl) amino) octanoate) (SM-102);
- DSPC;
- cholesterol;
- a poly[oligo (ethylene glycol) ether methacrylate] (POEGMA)-lipid conjugate at about 0.25 mol % to about 3 mol %, wherein the POEGMA has a number average molecular weight of about 1 kDa to about 50 kDa;
- and
- an mRNA.
Dependencies are inferred from the claim text.