Ammonium sulfate treated syringe for increased pharmaceutical composition stability
AssigneeBayer HealthCare LLC
InventorAndrew HAN
Life of this patent
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Abstract
Ammonium sulfate treated prefilled syringes, and kits that include an ammonium sulfate treated prefilled syringe and a pharmaceutical composition comprising an aluminum-sensitive active agent, are described herein. Treating the inner surface of a glass syringe barrel with ammonium sulfate prior to filling the syringe with a desired aqueous diluent, such as water for injection, can limit the amount of aluminum that leach into the aqueous diluent during storage.
Claims37
A kit, comprising:
- a prefilled syringe comprising an ammonium sulfate treated glass barrel containing an aqueous diluent;
- and
- a container containing a pharmaceutical composition comprising an aluminum-sensitive active agent.
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Dependencies are inferred from the claim text.