Systems and methods for treating an aortic tear or dissection

A method of treating an aortic tear or dissection of a subject, the method comprising:

• coupling a balloon with a central passage to an endoprosthesis, wherein an outer wall of said balloon comprises perforations or pores;
• inserting said endoprosthesis near an inlet flap of an aortic tear or dissection;
• expanding the endoprosthesis so that the balloon is in contact with aortic tissue;
• infusing a stabilization treatment compound through the balloon so that stabilization treatment compound weeps onto aortic tissue, said stabilization treatment compound comprising a contrast media agent, a stabilizing agent, and one or more excipients;
• and
• deflating and removing the balloon.

A method of treating an aortic tear or dissection, wherein the aortic tear or dissection comprises an inlet flap leading to a false lumen of a thoracic aorta separate from a true lumen of the thoracic aorta, the method comprising:

• placing a distal end of an infusion catheter inside the false lumen of the thoracic aorta,
• placing a stent in the true lumen of the thoracic aorta, and
• delivering a stabilization treatment compound through the infusion catheter into the false lumen, said stabilization treatment compound comprising a contrast media agent, a stabilizing agent, and one or more excipients,
• wherein said one or more excipients comprises solid poloxamer configured to biodegrade after at least 15 minutes of residence within the false lumen, wherein degradation of the solid poloxamer facilitates dispersion of the stabilizing agent.

A system for treatment of an aortic tear or dissection comprising:

• an endoprosthesis;
• an infusion catheter shaped to facilitate passage through or behind the endoprosthesis and extending beyond a distal end of the endoprosthesis;
• and
• a stabilizing treatment compound comprising a contrast agent, a stabilizing agent, and one or more excipients.

A method of treating a thoracic aortic aneurysm, comprising:

• placing a flow diverting catheter within a lumen of a thoracic aorta near a thoracic aortic aneurysm, said flow diverting catheter comprising an occlusive element on a proximal and/or distal end of the flow diverting catheter;
• infusing a stabilizing treatment compound to penetrate an aneurysmal wall, said stabilizing treatment compound comprising a contrast media agent, a stabilizing agent, and one or more excipients;
• aspirating remaining stabilizing treatment compound;
• and
• removing the flow diverting catheter.

A method of treating an aortic tear or dissection of a subject, the method comprising:

• inserting an infusion catheter near an inlet flap of the aortic tear or dissection;
• expanding the infusion catheter so that the infusion catheter is in contact with aortic tissue near the inlet flap;
• infusing a stabilization treatment compound through the infusion catheter, said stabilization treatment compound comprising a contrast media agent, a stabilizing agent, and one or more excipients;
• and
• removing the infusion catheter from the subject.

A method of treating an aortic tear or dissection of a subject, the method comprising:

• inserting an infusion catheter comprising two or more elongated balloons near an inlet flap of the aortic tear or dissection;
• expanding the infusion catheter so that the infusion catheter is in contact with aortic tissue near the inlet flap;
• wherein the two or more elongated balloons are coated with a stabilization treatment compound comprising a stabilizing agent and one or more excipients;
• and
• removing the infusion catheter from the subject.

A method of treating an aortic tear or dissection of a subject, the method comprising:

• inserting an infusion catheter comprising a catheter that may be actuated to form a spiral near an inlet flap of the aortic tear or dissection;
• expanding the infusion catheter by actuating the catheter to form a spiral such that the infusion catheter is in contact with aortic tissue near the inlet flap;
• infusing a stabilization treatment compound through the infusion catheter, said stabilization treatment compound comprising a contrast media agent, a stabilizing agent, and one or more excipients;
• inserting an endoprosthesis within loops of the spiral,
• removing the infusion catheter from the subject;
• and
• deploying the endoprosthesis near the inlet flap of an aortic tear or dissection.