Aortic ARCH Baroreceptor Implants for Treatment of Hypertension

An implant for treating hypertension in a patient, the implant comprising:

• an implant having a collapsed configuration for advancement through a vasculature of the patient and an expanded configuration for engagement of an arterial wall within an aortic arch of the patient,
• wherein the implant is dimensioned such that, when deployed in the aortic arch, has a length of at least 60 mm and the implant engages the arterial walls of the aorta and extends along a target zone that includes a region extending at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff;
• wherein the implant has a non-circular cross-section when expanded along its entire length so as to induce wall tension along entire target zone of the aortic arch so as to induce a baroreflex response of baroreceptors in the target zone;
• wherein the implant has sufficient flexibility to accommodate a curvature of the aortic arch along the elongated zone;
• and
• wherein any side openings in the implant are sufficiently large to allow lateral blood flow therethrough to any side branches and exposes the arterial walls to pulsatile blood flow.

A method for treating hypertension in a patient, said method comprising:

• deploying an implant within an aortic arch of the patient, the implant having a collapsed configuration for advancement through a vasculature of the patient and an expanded configuration for engagement of an arterial wall within an aortic arch of the patient, the implant having a length of at least 60 mm;
• engaging the arterial wall with the implant in the expanded configuration along a target zone that includes a region that extends at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff, wherein the implant has a non-circular cross-section when expanded thereby inducing wall tension along the target zone in the aortic arch;
• and
• exposing a majority of the arterial wall along the target zone to pulsatile blood flow side openings of the expandable structures so as to sustain the baroreflex response induced by the implant long-term.