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US 2025/0049409 A1Published application
Methods of quantifying skeletal muscle perfusion using pet imaging
OwnerMitchel Stacy, Ting-Heng Chouinventors
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Abstract
Described herein are methods for quantifying skeletal muscle perfusion, skeletal muscle metabolism, and active vascular calcification by positron emission tomography (PET) imaging of labeled radionuclides, such as 18F-labeled radionuclide agents.
Claims23
A method for quantifying skeletal muscle perfusion in a tissue of a subject, comprising:
- (i) administering to the subject an effective amount of a fluorine-18-labeled radionuclide agent;
- (ii) dynamically imaging the subject on a positron emission tomography (PET) system, wherein the imaging begins at least about 1 second prior to step (i);
- and
- (iii) performing kinetic modeling of the PET imaging data following steps (i) and (ii).
1 more element
A method for quantifying skeletal muscle metabolism in a tissue of a subject, the method comprising the steps of:
- (i′) administering to the subject an effective amount of a fluorine-18-labeled glucose or analog thereof;
- (ii′) dynamically imaging the patient on a positron emission tomography (PET) system for about 5 to 60 minutes following step (i′);
- and
- (iii′) performing three-tissue compartment kinetic modeling of the PET imaging data following steps (i′) and (ii′).
1 more element
A method for quantifying active vascular calcification in a subject's blood vessel, comprising:
- (a) administering to the subject an effective amount of fluorine-18-labeled sodium fluoride;
- (b) dynamically imaging the subject using a positron emission tomography (PET) system;
- and
- (c) following step (b), imaging the subject a second time using the positron emission tomography (PET) system, wherein a second dose of fluorine-18-labeled sodium fluoride or another fluorine-18-labeled radionuclide agent is not administered to the subject between step (b) and (c).
1 more element
Dependencies are inferred from the claim text.