Blood glucose estimation using near infrared light emitting diodes

A continuous non-invasive sensor system having a multi-sensing detection device, the sensor system for employing spectral related skin response data for determining a light signature from which a concentration of glucose being present in a tissue of a body of a wearer of the multi-sensing detection device may be determined, the system comprising:

• an attachment structure formed as a patch having an inner portion and an outer portion, the outer portion including a surface having an adhesive so as to hold the patch against the wearer's skin;
• a multi-sensing detection device retained within the inner portion of the patch and being configured for being positioned proximate the skin of the wearer when the patch is adhered to the skin of the wearer, the multi-sensing detection device having a glucose sensor unit for detecting glucose being present within the wearer's tissue, the multi-sensing detection device comprising:
• a housing configured for engaging with the attachment structure in a manner so as to be held against the skin of the wearer, the housing further being configured for encasing the glucose sensor unit, the housing having a top cover and a bottom cover, the bottom cover including a transparent window positioned therein;
• a glucose sensor unit for detecting a skin characteristic response of one or more tissues of the body due to a presence of glucose within the body tissue, the glucose sensor unit comprising:
• a printed circuit board having a first and a second sensor array coupled therewith, each sensor array including a number of photoemitters and one or more photoreceivers, each sensor array being arranged on the printed circuit board within in the housing proximate the transparent window opposite the user's body tissue, the one or more photoemitters configured to illuminate, at a predetermined frequency and duration of light, the user's tissue below the transparent window, and each of the one more photoreceivers configured to receive a return of the light reflected back from the user's tissue below the transparent window and to generate a return signal in response to collecting the reflected light,
• the first sensor array comprising six photoemitters positioned so as to surround at least a first photoreceiver and being configured for directing light so as to penetrate a determined depth within the tissue of the body, the six photoemitters including a first photoemitter formed of a first light emitting diode configured for emitting light of a first wavelength, a second photoemitter formed of a second light emitting diode configured for emitting light of a second wavelength, a third7ujn photoemitter formed of a third light emitting diode configured for emitting light of a third wavelength, a fourth photoemitter formed of a fourth light emitting diode configured for emitting light of a fourth, a fifth photoemitter formed of a fifth light emitting diode configured for emitting light of a fifth wavelength, and a sixth photoemitter formed of a sixth light emitting diode configured for emitting light of a sixth wavelength, wherein the first photoreceiver is configured for detecting light of the six photoemitters reflected back from the body's tissues, and
• the second sensor array comprising four photoemitters positioned so as to surround at least a second photoreceiver, the four photoemitters including a seventh photoemitter formed of a seventh light emitting diode configured for emitting light of a seventh wavelength, an eighth photoemitter formed of a eighth light emitting diode configured for emitting light of an eighth wavelength, a ninth photoemitter formed of a ninth light emitting diode configured for emitting light of a ninth wavelength, and a tenth photoemitter formed of a tenth light emitting diode configured for emitting light of a tenth wavelength, wherein the second photoreceiver is configured for detecting light of the four photoemitters reflected back from the body's tissues, collectively the light emitting diodes of the first and second sensory array are configured for directing the emitted light of their respective wavelengths into the tissue of the wearer, and the at least first and second photoreceivers are configured for collecting the light reflected back form the body tissue so as to generate the return signal,
• the printed circuit board further comprising an analog to digital converter coupled to the at least first and second photoreceivers, the analog to digital converter being configured for converting the return signal to digital signal data, and a communications module for transmitting the digital signal data;
• and
• a server system for receiving the digital signal data from the multi-sensing detection device, the server system comprising a first processing module having a first processor for analyzing the digital signal data so as to produce light signature data, and a second processor for analyzing the light signature data so as to thereby determine the concentration of glucose being present in the tissue of the body of the wearer.

A continuous non-invasive sensor system having a multi-sensing detection device, the sensor system for employing diffuse reflectance spectrum analysis for determining a skin response from which a concentration of an analyte being present in a skin tissue of a body of a wearer of the multi-sensing detection device may be determined, the system comprising:

• an attachment structure having an inner portion and an outer portion, the inner portion for engaging with the multi-sensing detection device, and the outer portion including a surface having an adhesive so as to hold the attachment structure against the wearer's skin;
• and
• a multi-sensing detection device retained within the inner portion of the attachment structure and being configured for being positioned proximate the skin of the wearer when the attachment structure is adhered to the skin of the wearer, the multi-sensing detection device having an analyte sensor unit for detecting a specific analyte being present within the wearer's tissue, the multi-sensing detection device comprising:
• a housing configured for engaging with the attachment structure in a manner so as to be held against the skin of the wearer, the housing further being configured for encasing the analyte sensor unit, the housing having a top cover and a bottom cover, the bottom cover including a transparent window positioned therein;
• an analyte sensor unit for detecting a characteristic response of the skin to a spectral array to of one or more skin tissues of the body due to a presence of the analyte within the skin tissue, the analyte sensor unit comprising:
• a printed circuit board having a first and a second sensor array coupled therewith, each sensor array including a number of photoemitters and one or more photoreceivers, each sensor array being arranged on the printed circuit board within in the housing proximate the transparent window opposite the user's body tissue, the one or more photoemitters configured to illuminate, at a predetermined frequency and duration of light, the user's tissue below the transparent window, and each of the one more photoreceivers configured to receive a return of the light reflected back from the user's tissue below the transparent window and to generate a return signal in response to collecting the reflected light,
• the first sensor array comprising six photoemitters positioned so as to form a shape approximating a circle surrounding at least a first photoreceiver, the six photoemitters including a first photoemitter formed of a first light emitting diode configured for emitting light of a wavelength of about 1050 nm, a second photoemitter formed of a second light emitting diode configured for emitting light of a wavelength of about 1200 nm, a third photoemitter formed of a third light emitting diode configured for emitting light of a wavelength of about 1300 nm, a fourth photoemitter formed of a fourth light emitting diode configured for emitting light of a wavelength of about 1450 nm, a fifth photoemitter formed of a fifth light emitting diode configured for emitting light of a wavelength of about 1550 nm, and a sixth photoemitter formed of a sixth light emitting diode configured for emitting light of a wavelength of about 1650 nm, wherein the first photoreceiver is configured for detecting light of the six photoemitters reflected back from the body's tissues, and
• the second sensor array comprising four photoemitters positioned so as to form a shape approximating a square surrounding at least a second photoreceiver, the four photoemitters including a seventh photoemitter formed of a seventh light emitting diode configured for emitting light of a wavelength of about 450 nm, an eighth photoemitter formed of a eighth light emitting diode configured for emitting light of a wavelength of about 650 nm, a ninth photoemitter formed of a ninth light emitting diode configured for emitting light of a wavelength of about 750 nm, and a tenth photoemitter formed of a tenth light emitting diode configured for emitting light of a wavelength of about 950 nm, wherein the second photoreceiver is configured for detecting light of the four photoemitters reflected back from the body's tissues, collectively the light emitting diodes of the first and second sensory array are configured for directing the emitted light of their respective wavelengths into the tissue of the wearer, and the at least first and second photoreceivers are configured for collecting the light reflected back form the body tissue so as to generate the return signal,
• the printed circuit board further comprising an analog to digital converter coupled to the at least first and second photoreceivers, the analog to digital converter being configured for converting the return signal to digital signal data, and a communications module for transmitting the digital signal data;
• and
• a control unit coupled to the printed circuit board, the control unit configured to generate activation of each of the photoemitters, whereby each photoemitter of the first and second sensor arrays may be activated individually or collectively in one or more of a predetermined wavelength, a predetermined frequency, a predetermined intensity, and a predetermined duration.