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US 2025/0049096 A1Published application
Vaporizable alkaloid compositions and methods of use thereof
AssigneeReady Mix Naturals, LLC
InventorsCharlotte L. OWEN, Richard AVILA, JR., Geoff W. HABICHT
Life of this patent
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Abstract
In various embodiments of the present disclosure, vaporizable alkaloid compositions comprising a substituted pyridine compound of Formula (I) and entirely absent nicotine are described that are capable of forming an inhalable vapor when dispensed from an electronic device such as an e-cigarette. A series of such vaporizable alkaloid compositions having decreasing (w/v) amounts of substituted pyridine compound are provided as part of a smoking cessation program.
Claims20
A vaporizable alkaloid composition, comprising:
- at least one substituted pyridine compound of Formula (I):
- or a salt, or mixed salt thereof, wherein:
- A is selected from:
- R1, R2, R3, R4 and R5 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, and
- R6 and R7 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl and substituted alkenyl, or R6 and R7 together are ═O;
- R8, R9, R10, R11, and R12 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, and substituted alkenyl;
- R13 and R14 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, and substituted alkenyl, or R13 and R14 together are ═O;
- n is an integer from 1 to 10;
- and
- R15 and R16 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl and substituted alkenyl, or R15 and R16 together with the N atom to which they are bonded form a 3-8 membered optionally substituted heterocyclic ring,
- with the proviso that if A is
- and R5 is methyl, then R1, R2, R3, R4, R6, R7, R8, R9, R10, and R11 cannot all be H;
- and
- at least one solvent,
- wherein the vaporizable alkaloid composition is entirely devoid of (R) or (S) nicotine.
12 more elements
A vaporizable alkaloid composition comprising:
- (a) from about 1 wt. % to about 80 wt. % of a substituted pyridine compound of Formula (I):
- or a salt, or mixed salt thereof, wherein:
- A is selected from:
- R1, R2, R3, R4 and R5 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, and
- R6 and R7 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl and substituted alkenyl, or R6 and R7 together are ═O;
- R8, R9, R10, R11, and R12 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, and substituted alkenyl;
- R13 and R14 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, and substituted alkenyl, or R13 and R14 together are ═O;
- n is an integer from 1 to 10;
- and
- R15 and R16 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl and substituted alkenyl, or R15 and R16 together with the N atom to which they are bonded form a 3-8 membered optionally substituted heterocyclic ring,
- with the proviso that if A is
- and R5 is methyl, then R1, R2, R3, R4, R6, R7, R8, R9, R10, and R11 cannot all be H;
- (b) from about 0.05 wt. % to about 1.5 wt. % in total of at least one organic acid;
- and
- (c) remainder solvent,
- wherein the weight percentages are based on the total weight of the vaporizable alkaloid composition;
- and
- wherein the molar ratio of moles of substituted pyridine compound to total moles of organic acid is from about 25:1 to about 75:1.
15 more elements
A method for promoting smoking cessation in an individual desirous of cessation, the method comprising:
- administering to the individual, over a time period determined for cessation, a series of vaporizable alkaloid compositions for the individual to inhale by vaping, each vaporizable alkaloid composition in the series comprising at least one substituted pyridine compound according to Formula (I):
- or a salt, or mixed salt thereof, wherein:
- A is selected from:
- R1, R2, R3, R4 and R5 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, and
- R6 and R7 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl and substituted alkenyl, or R6 and R7 together are ═O;
- R8, R9, R10, R11, and R12 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, and substituted alkenyl;
- R13 and R14 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, and substituted alkenyl, or R13 and R14 together are ═O;
- n is an integer from 1 to 10;
- and
- R15 and R16 are independently selected from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl and substituted alkenyl, or R15 and R16 together with the N atom to which they are bonded form a 3-8 membered optionally substituted heterocyclic ring,
- with the proviso that if A is
- and R5 is methyl, then R1, R2, R3, R4, R6, R7, R8, R9, R10, and R11 cannot all be H;
- and at least one solvent;
- wherein each of the vaporizable alkaloid compositions in the series of vaporizable alkaloid compositions comprises a decreasing (w/v) amount of said substituted pyridine compound of Formula (I), or salt, or mixed salt thereof;
- wherein the series of vaporizable alkaloid compositions includes a vaporizable alkaloid composition having a highest (w/v) level of said substituted pyridine compound of Formula (I), or salt, or mixed salt thereof, and includes a vaporizable alkaloid composition having a lowest (w/v) level of said substituted pyridine compound of Formula (I), or salt, or mixed salt thereof;
- and
- wherein the individual inhales by vaping each composition in the series beginning at a start of the time period determined for cessation with the vaporizable alkaloid composition having the highest level (w/v) of said substituted pyridine compound of Formula (I), or salt, or mixed salt thereof, and ending at an end of the time period determined for cessation with the composition having the lowest level (w/v) of said substituted pyridine compound of Formula (I), or salt, or mixed salt thereof, such that at commencement of the time period determined for cessation the individual ceases smoking.
14 more elements
Dependencies are inferred from the claim text.