Humanized mouse models of the fcrn recycling pathway
AssigneeThe Jackson Laboratory
InventorsMichael V. Wiles, Derry C. Roopenian, Gregory Christianson, Benjamin E. Low
Life of this patent
Estimating the term…
Abstract
The present disclosure provides improved humanized IgG1 FCRN mouse models for use, for example, in estimating serum half-life of therapeutic proteins such as monoclonal antibodies.
Claims10
A mouse comprising a nucleic acid encoding human neonatal Fc receptor (FCRN) and a nucleic acid encoding a chimeric immunoglobulin that comprises a human immunoglobulin gamma (IgG) Fc region and a mouse Fab region, wherein the mouse comprises a null mutation in endogenous FcRn.
-14. (canceled)
A nucleic acid or set of nucleic acids encoding a chimeric immunoglobulin that comprises a human immunoglobulin gamma (IgG) Fc region and a mouse Fab region.
A chimeric immunoglobulin comprising a human immunoglobulin gamma (IgG) Fc region and a mouse Fab region.
Dependencies are inferred from the claim text.