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US 2025/0043344 A1Published application
Sequencing and high resolution imaging
AssigneePacific Biosciences of California, Inc.
InventorsBryan P. STAKER, Niandong LIU, Manohar R. FURTADO, Rixun FANG, Norman BURNS, Windsor OWENS
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Abstract
Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. There have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy or polynucleotide sequencing applications.
Claims20
-20. (canceled)
A method of identifying an analyte, comprising:
- (a) binding a first probe to a first analyte to generate a first optical signal;
- (b) detecting said first optical signal with an imaging system, wherein said imaging system detects said first optical signal from said substrate with a resolution of up to about 300 nanometers per pixel of said imaging system;
- and
- (c) using said detected first optical signal to identify said first analyte.
1 more element
Dependencies are inferred from the claim text.