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US 2025/0043247 A1Published application
Sc-beta cells and compositions and methods for generating the same
AssigneePresident and Fellows of Harvard College
InventorsQuinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey Robert Millman, Michael Saris Segel, Mads Gurtler
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Abstract
Disclosed herein are methods, compositions, kits, and agents useful for inducing β cell maturation, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
Claims28
A composition comprising a thyroid hormone signaling pathway activator, a protein kinase C inhibitor, and a plurality of NKX6.1-positive, PDX1-positive cells.
Dependencies are inferred from the claim text.