Method for preparing aryl carbon glycoside compound including gliflozin drug

A method for preparing aryl C-glycosides, characterized in that the method comprises the following steps:

• a glycosyl donor represented by formula W, a glycosyl acceptor represented by formula B-1, Ni(II) catalyst, a photosensitizer, a ligand, and a base are added to a solvent, and then allowed to react under light, to obtain an aryl C-glycoside represented by formula B-2;
• wherein, n is selected from 0 or 1;
• a is selected from 3 or 4;
• R is each independently selected from L1Rx;
• alternatively, two adjacent R are linked to form a ring, and additional R is independently selected from L1Rx, wherein the ring is unsubstituted or substituted with one or more L1Rx;
• L1 is selected from absence or C1-2 alkylene;
• Rx is selected from the group consisting of H, hydroxyl, C1-6 alkyl, OAc, OBn, OR8, NR9R10,
• Ph, amino,
• i is an integer selected from 0 to 6;
• R11, R12, R13, and R14 are each independently selected from L2Ry;
• L2 is selected from absence or C1-2 alkylene, and Ry is selected from the group consisting of H, hydroxyl, C1-6 alkyl, OAc, OBn, OR8, and NR9R10;
• R8 is selected from C1-6 alkyl;
• R9 is selected from the group consisting of H, C1-6 alkyl, Ac, and Bn;
• R10 is selected from the group consisting of H, C1-6 alkyl, Ac, and Bn;
• j is 1, 2, or 3;
• Mj+ is a j-valent cation;
• X is halogen;
• Rb1 is selected from the group consisting of H, hydroxyl, C1-6 alkyl, C1-6 alkoxy, and halogen;
• Rb2 is selected from the group consisting of H and
• wherein ring A is selected from the group consisting of 5-6-membered aryl, 5-6 membered heteroaryl, fused cycloalkyl, or fused heterocyclic group;
• p is an integer from 0 to 2;
• Rb3 is each independently selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, halogenated or unhalogenated phenyl, and ORb4, and Rb4 is selected from 5-6-membered saturated heterocyclic group or 5-6 membered saturated cycloalkyl.