Chromophoric polymer dots
AssigneeUniversity of Washington through its Center for Commercialization
InventorsDaniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
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Abstract
The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
Claims20
A chromophoric nanoparticle comprising a chromophoric polymer comprising a plurality of monomeric units, wherein less than 50% of the monomeric units present in the chromophoric nanoparticle are modified with a hydrophilic moiety, and wherein at least one of the monomeric units are modified with a hydrophilic functional group suitable for conjugation.
A plurality of chromophoric nanoparticles, wherein chromophoric nanoparticles of the plurality of chromophoric nanoparticles comprise:
- a chromphoric polymer comprising a plurality of monomeric units, wherein less than 50% of monomeric units present in the nanoparticle are modified with a hydrophilic moiety, wherein at least one of the monomeric units is modified with a hydrophilic functional group suitable for conjugation.
A chromophoric nanoparticle bioconjugate comprising:
- a chromophoric nanoparticle comprising a chromophoric polymer comprising a plurality of monomeric units, wherein less than 50% of monomeric units present in the chromophoric nanoparticle are modified with a hydrophilic moiety;
- and
- a biomolecule attached to the chromophoric polymer.
Dependencies are inferred from the claim text.