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US 2025/0034597 A1Published application
RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci
AssigneeThe General Hospital Corporation
InventorsJ. Keith Joung, Morgan Maeder
Life of this patent
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Abstract
Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci.
Claims12
-25. (canceled)
A mammalian cell expressing a fusion protein comprising a catalytically inactive S. pyogenes Cas9 protein linked to a heterologous functional domain, wherein the catalytically inactive Cas9 protein comprises mutations at D10 and H840.
Dependencies are inferred from the claim text.