On-line biomolecular analysis for monitoring or controlling bioprocesses

A manifold adapted to provide at least one fluid sample to an analyzer in a system for measuring at least one analyte in the fluid sample, the manifold comprising:

• a body,
• in the body, for each fluid sample to be analyzed, one fluidic cell comprising one fluid distribution channel and a collecting channel in fluidic communication with the fluid distribution channel;
• wherein a fluid distribution tubing can be fitted with the fluid distribution channel, so that it is emerging in the collecting channel, and wherein a sample taker can be contacted with at least a drop of the fluid sample emerging at a top of the fluid distribution tubing as the contact volume and can transfer an aliquot from the fluid sample to an analyzer for measurement and/or analysis;
• or
• wherein the fluid distribution tubing can be fitted with the fluid distribution channel in fluidic connection with a measurement well, so that the measurement well can be filled with the fluid sample, and wherein the sample taker can be immerged in the measurement well so that it can take an aliquot from the fluid sample and transfer it to an analyzer for measurement and/or analysis;
• and wherein the collecting channels are is plunging so that the fluid sample can be collected per gravity.

A system for measuring one or more analytes in discrete fluid samples from a vessel adapted to contain a fluid, the system comprising:

• at least one sensor for the measurement of at least one analyte in a contact volume of the fluid sample;
• an analysis module comprising at least one main sampling line in fluidic connection with the vessel and at least one pump in fluidic connection with the at least one sampling line and adapted to selectively pump fluid from in the at least one main sampling line away from the vessel;
• at least one fluid distribution tubing in fluidic connection with the analysis module;
• a manifold comprising a body, and in the body, for each sensor, one fluidic cell comprising one fluid distribution channel and a collecting channel in fluidic communication with the fluid distribution channel;
• wherein the at least one fluid distribution tubing is fitted with the fluid distribution channel so that it is emerging in the collecting channel and so that the at least one sensor can be contacted with at least a drop of the fluid sample emerging at a top of the at least one fluid distribution tubing as the contact volume;
• or
• wherein the at least one fluid distribution tubing is fitted with the fluid distribution channel in fluidic connection with a measurement well, so that the measurement well can be filled with the fluid sample to create the contact volume and the at least one sensor can be dipped in the contact volume for measurement;
• and wherein the collecting channels is plunging so that the fluid sample can be collected per gravity.