Ang (1-7) derivative oligopeptides and methods for using and producing the same
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMeredith Hay, John Konhilas, Robin L. Polt, Evan Jones, Lajos Szabo
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Abstract
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
Claims1
A method for treating cognitive dysfunction in a subject diagnosed as having a cognitive dysfunction comprising systemically administering to the subject a therapeutically effective amount of an octapeptide having the formula:
- A1-A2-A3-A4-A5-A6-A7-A8 (SEQ ID NO:
- 1) wherein
- A1 is selected from the group consisting of aspartic acid, glutamic acid, and alanine;
- A2 is selected from the group consisting of arginine, histidine, and lysine;
- A3 is selected from the group consisting of valine, alanine, isoleucine, and leucine;
- A4 is selected from the group consisting of tyrosine, phenylalanine, and tryptophan;
- A5 is selected from the group consisting of isoleucine, valine, alanine, and leucine;
- A6 is selected from the group consisting of histidine, arginine, and lysine;
- A7 is proline, glycine, serine, and glycosylated serine;
- and
- A8 is serine, threonine, hydroxyproline, and glycosylated forms thereof.
Dependencies are inferred from the claim text.