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US 2025/0034193 A1Published application
Phenothiazine derivatives and uses thereof
AssigneeCamp4 Therapeutics Corporation
InventorsDavid A. Bumcrot, Alfica Sehgal, Donald L. Hertzog
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Abstract
The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).
Claims21
1-128. (canceled)
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is selected from —OH, and C1-6alkoxy;
- R2 and R3 are taken together with the carbon to which R2 and R3 are attached to form a 3-7 membered heterocyclylene, wherein the heterocyclylene may be optionally substituted with one or more oxo or C1-6alkyl and have one or more heteroatoms, wherein each of the heteroatoms is nitrogen;
- each R4 is oxo;
- X is NR7 or CH2, wherein the hydrogen(s) of CH2 may be substituted with R4;
- R7 is hydrogen or C1-6alkyl;
- n is 1 or 2;
- m is 0 or 1;
- and
- p is selected from the group consisting of 0, 1, 2, 3, and 4.
7 more elements
A compound of formula (III):
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is selected from hydrogen, —OH, and C1-6alkoxy;
- n is 1 or 2;
- m is selected from 1, 2, or 3;
- and
- is a monosaccharide or disaccharide.
3 more elements
Dependencies are inferred from the claim text.