Quaternary phosphonium compounds and uses thereof
AssigneesEmory University, Villanova University
InventorsWilliam Wuest, Kevin Minbiole
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Abstract
This disclosure relates to quaternary phosphonium compounds having lipophilic groups. In certain embodiments, this disclosure relates to quaternary phosphonium compounds having chemical formula as reported herein. In certain embodiments, this disclosure relates to compositions and devices comprising or coated with quaternary phosphonium compounds disclosed herein. In certain embodiments, this disclosure relates to preventing or treating a microbial infection or cancer using quaternary phosphonium compounds disclosed herein.
Claims21
A quaternary phosphonium compound having Formula I,
- wherein
- R1 is a lipid and
- R2, R3, and R4 are each individually and independently selected from hydrogen, alkyl, alkoxy, or halogen, wherein R2, R3, and R4 are optionally substituted.
A quaternary phosphonium compound having Formula II,
- wherein,
- R1 is a lipid;
- X is a linking group;
- and
- R2, R3, and R4 are each individually and independently selected from hydrogen, alkyl, alkoxy, or halogen, wherein R2, R3, and R4 are optionally substituted.
A quaternary phosphonium compound having Formula III,
- wherein,
- R1 is a lipid;
- X is a linking group;
- and
- R2, R3, and R4 are each individually and independently selected from hydrogen, alkyl, alkoxy, or halogen, wherein R2, R3, and R4 are optionally substituted.
A quaternary phosphonium compound having Formula IV,
- wherein,
- R1 is a lipid;
- X is a linking group;
- and
- R2, R3, and R4 are each individually and independently selected from hydrogen, alkyl, alkoxy, or halogen, wherein R2, R3, and R4 are optionally substituted.
Dependencies are inferred from the claim text.