Amine compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity

A compound represented by Formula I or a pharmaceutically acceptable salt thereof,

• G-NH-A-Q-X-Y-Z I
• wherein
• G is a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms, either unsubstituted or substituted
• at a ring carbon by amino, dimethylamino, hydroxy, halo, methyl, perfluoromethyl, or alkyl having from 1 to 16 carbon atoms either unsubstituted or substituted by hydroxy or alkoxy having 1 to 12 carbon atoms or acetoxy;
• or at a ring nitrogen by alkyl having from 1 to 16 carbon atoms either unsubstituted or substituted by hydroxy or alkoxy having from 1 to 8 carbon atoms;
• N is nitrogen, H is hydrogen, and NH is absent or present;
• A is absent or present and is alkyl having from 1 to 12 carbon atoms, provided that if A has 1 carbon atom Q must be absent;
• Q is absent or present and is O, NHC(O), or NH, provided that if A is absent Q must be absent, and if both X and Y are absent Q cannot be O or NH;
• X is absent or present and is alkyl having from 1 to 5 carbon atoms, provided that if Y is absent and Z is alkoxy or phenoxy X must have more than 1 carbon atom;
• Y is absent or present and is phenyl unsubstituted or substituted by halo, or is a monocyclic or bicyclic aromatic ring having one or two nitrogen atoms;
• Z is absent or present and is hydrogen, alkyl having from 1 to 12 carbon atoms either unsubstituted or substituted by one phenyl or phenoxy group, alkoxy having from 1 to 12 carbon atoms either unsubstituted or substituted by one phenyl or phenoxy group, phenyl, phenoxy, or NHC(O)R6 or C(O)NHR6 or C(O)OR6 where R6 is alkyl having from 1 to 6 carbon atoms, provided that if all of A, Q, X, and Y are absent then Z must be alkyl having 6 to 12 carbon atoms.