Small molecule inhibitors of lanosterol synthase

A compound of formula I:

• or a salt, hydrate or stereoisomer thereof, wherein:
• Q is selected from cyclopropane-1,2-diyl, CH2, (CH2)2, O;
• X, Y, Z and W are each independently selected from CR and N;
• R=H, halogen (e.g. F, Cl, Br);
• CH3, optionally fluorinated (e.g. CF3), optionally deuterated (e.g. CD3);
• L is selected from:
• —OCHRC(O)—[R=H, Me, CF3, CHF2, CH2F], —NHCH2C(O)—, —NHCHMeC(O)—, —NMeCH2C(O)—, —NMeCHMeC(O)—, —SCH2C(O)—, —SCHMeC(O)—, —CH2OC(O)—, —CHMeOC(O)—, —CH2NHC(O)—, CHMeNHC(O)—, —OCH2NMeC(O)—, —CHMeNMeC(O)—, —CH2NHSO2-, —CHMeNHSO2-, —CH2NMeSO2-, —CMeNMeSO2-, —O(CH2)n- [n=0-2], —OCHMe-, —OCHMeCH2-, —OCH2CHR—[R=Me, OH, OMe, OCF3, OCHF2, OCH2F], —OCHMeCHR—[R=OH, OMe, OCF3, OCHF2, OCH2F], —(CH2)nC(O)—[n=0-2], —CHRCH2C(O)—[R=Me, OH, OMe, OCF3, OCHF2, OCH2F], —CH2CHRC(O)—[R=Me, OH, OMe, OCF3, OCHF2, OCH2F], —CHORCH2n- [n=0-2;
• R=H, Me, CF3, CHF2, CH2F], —(CH2)nCHOR— [n=1-2;
• R=H, Me, CF3, CHF2, CH2F], —CHORCH2CHOR′—[R, R′ independently selected from H, Me, CF3, CHF2, CH2F], —CHORCHMeCHOR′—[R, R′ independently selected from H, Me, CF3, CHF2, CH2F], —CHORCMeCH2- [R=H, Me, CF3, CHF2, CH2F], —CH(OR)CH═CH—[R=H, Me, CF3, CHF2, CH2F], —(CH2)n- [n=0-3], —CH2NR—[R=H, Me]-, —CH═CHC(O)—, CH═CHCHR—[R=OH, OMe, OCF3, OCHF2, OCH2F], —CMe=CHC(O)—, CH═CMeC(O)—, CMe=CHCHOR—[R=H, Me, CF3, CHF2, CH2F], CH═CMeCHOR [R=H, Me, CF3, CHF2, CH2F], —C≡CC(O)—, —C≡CCHR [R=H, Me, OH, OMe, OCF3, OCHF2, OCH2F], -(cyclopropane-1,2-diyl)C(O)—, -(cyclopropane-1,2-diyl)CHR—[R=H, Me, OH, OMe, OCF3, OCHF2, OCH2F], -(oxiran-2,3-diyl)C(O)—, -(oxiran-2,3-diyl)CHR—[R=H, Me, OH, OMe, OCF3, OCHF2, OCH2F], —C(O)(cyclopropane-1,2-diyl)-, —CHR(cyclopropane-1,2-diyl)- [R=H, Me, OH, OMe, OCF3, OCHF2, OCH2F], —C(O)(oxiran-2,3-diyl)-, —CHR(oxiran-2,3-diyl)- [R=H, Me, OH, OMe, OCF3, OCHF2, OCH2F];
• and
• Ar is selected from 2-, or 3- or, 4-mono- or, di- or trisubstituted phenyls (with preferred substituents selected from halogen (e.g. F, Cl, Br), Me or OMe, cycloPr, CN, —NHCHO, each optionally fluorinated and optionally deuterated (e.g. OCF3, CF3, CD3);
• and optionally substituted phenyls and heteroaryls), mono- and fused bicyclic heteroaryl, fused heteroaryl [e.g. pyridine;
• pyrimide, pyrazine, pyridazine, oxazole, benzoxazole, pyrrazole, quinoline, quinoxaline, isoquinoline], biaryls and fused aryls (naphtyls);
• each optionally fluorinated and optionally deuterated (e.g. OCF3, CF3, CD3);
• with optional substituents selected from halogen (e.g. F, Cl, Br), CF3, Me or OMe, cPr, CN, aryl, and heteroaryl, each optionally fluorinated and optionally deuterated (e.g. OCF3, CF3, CD3).