Prevention and treatment of depressive disorders and conditions promoted by protease containing plasma extracellular vesicles (PCpEV)

A method of treatment or prevention of a condition selected from the group consisting of:

• major depressive disorder, mood disorders, anxiety-related disorders and depression associated with diseases or drug treatments, HIV associated neurocognitive disorders (HAND), psoriasis, chronic fatigue syndrome, Parkinson's disease, Long COVID syndrome, drug treatment regimens with IFN-alpha or vitamin A analogues, and substance abuse symptoms, the method comprising a step of administering to a patient having said condition a pharmaceutically effective amount of compound having the structure of Formula;
• wherein R is H, a phosphate, ester, monosaccharide, or disaccharide;
• or a salt thereof.

A method to modify the presence of hyaluronic acid (HA), and/or cleavage products of HA i-on the surface of extracellular vesicles (EV) or vesicular structures prepared for therapeutic use, via stable or transient transfection of an expression plasmid to an eukaryotic cell producing said vesicles or, alternatively, synthesizing said vesicles in vitro for the delivery of molecular cargo for use in targeting immune cells or the brain for therapeutic, preventive and/or age-reversing effects.

(canceled)