Devices, systems, and methods for pyloric occlusion

A system for delivering an occlusion device across a pylorus, the system comprising:

• an occlusion device;
• and
• a delivery device including an inner member having a guidewire and a retractable outer sheath, the inner member and the outer sheath being operable to constrain the occlusion device therebetween prior to deployment;
• wherein the occlusion device includes:
• a first flange;
• a second flange connected to the first flange by a saddle region defining a lumen, the second flange being proximal to the first flange;
• and
• a closure element, wherein the closure element is configured to occlude a flow of material through the lumen upon deployment of the device, and to continue to occlude flow of material after deployment of the device.

A method of occluding a pylorus, the method comprising:

• deploying a first flange of a pyloric occlusion device against a duodenum side of the pylorus;
• extending an occluded saddle region of the pyloric device across the pylorus to occlude the pylorus upon deployment;
• and
• deploying a second flange of a pyloric occlusion device against a gastric side of the pylorus.